|
KMID : 0363620170380010072
|
|
Journal of Korean Oriental Medicine
2017 Volume.38 No. 1 p.72 ~ p.80
|
|
|
Correlation Analysis of Organic Acid Comprehensive Profile Markers with Chemotherapy Induced Peripheral Neuropathy in Cancer Patients
|
|
Park Ji-Hye
Sung Simon Sang-Yup
Lee Jin-Sun
Yoo Hwa-Seung
|
|
|
Abstract
|
|
|
Objectives: The purpose of this study is to evaluate the urinary organic acid comprehensive profile for chemotherapy induced peripheral neuropathy (CIPN).
Methods: Participants are 66 patients with CIPN who had symptom (Visual analog scale ≥ 30 mm, Eastern Cooperative Oncology Group ≤ 2). Participants were tested with organic acid comprehensive profile markers.
Results: Positive Correlation was observed in the neurotransmitter metabolism markers, N-methyl-D-aspartate (NMDA) modulators markers, detoxification markers, energy production markers, amino acid metabolism markers, and intestinal dysbiosis markers. Especially, all the neurotransmitter metabolism markers were showed positive rate of 44%. In addition, neuro-endo-immune was associated with energy metabolism (mitochondrial dysfunction) in CIPN of cancer patient. especially detoxification, intestinal bacterial hyperplasia, vitamin deficiency (folate, complex B group, vitamin C).
Conclusions: Significant urinary organic acid comprehensive profile results were obtained in cancer patients who induced peripheral neuropathy by chemotherapy.
|
|
|
KEYWORD
|
|
|
Chemotherapy induced peripheral neuropathy, Urinary organic acid, Neurotransmitter metabolism, Bio markers
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|